Noun
An intensely poisonous alkaloid, extracted from aconite.
Source: Webster's dictionaryCYP2C8 and 2C9 had a minor role to the aconitine metabolism, whereas CYP1A2, 2E1 and 2C19 did not produce any aconitine metabolites at all. Source: Internet
Aconitine is the toxic ingredient of Radix Aconiti, which often causes arrhythmia. Source: Internet
The toxic effects of aconitine were attenuated by tetrodotoxin, probably due to their mutual antagonistic effect on excitable membranes. citation Also Paeoniflorin seems to have a detoxifying effect on the acute toxicity of aconitine in test animals. Source: Internet
New sensitive HPLC-MS methods have been developed as well, usually preceded by SPE purification of the sample. citation The antiarrhythmic drug lidocaine has been reported to be an effective treatment of aconitine poisoning of a patient. Source: Internet
Successful use of charcoal hemoperfusion has been claimed in patients with severe aconitine poisoning. citation Poisoning may also occur following picking the leaves without wearing gloves; the aconitine toxin is absorbed easily through the skin. Source: Internet
The results indicate that aconitine was mainly metabolized by CYP3A4, 3A5 and 2D6. Source: Internet