"After everything" means considering all that has happened or been done so far. It often highlights a final stance, surprise, or gratitude despite past events.
After everything that's happened, how can the world still be so beautiful? Because it is. Margaret Atwood
After everything that happened, how could I miss him? But I did, I did. Sarah Dessen
So that's it? Your just going to give up?! After everything that has happened, your not going to even try?! You still don't know..... what truly matters. Masashi Kishimoto
He was a gentle and sensitive soul, and therefore had a short temper, which is why he went straight after everything with an ax... Bohumil Hrabal
Being with him after so long, after everything we'd endured... it was like coming home. Richelle Mead
After everything he'd built, planned, fought for, fretted over, dreamed of, this was the summation of his life; one disappointing son and two suitcases. Khaled Hosseini