allopurinol
Noun
Meaning
a drug (trade name Zyloprim) used to treat gout and other conditions in which there is an excessive buildup of uric acid
Source: WordNetSynonyms
Hypernyms
Examples
Adjunctive allopurinol is safe, effective, and well tolerated in inflammatory bowel disease patients who do not respond adequately to thiopurines due to hypermethylation.
Some practitioners advocate adding allopurinol only in people in whom hyperuricosuria and hyperuricemia persist, despite the use of a urine- alkalinizing agent such as sodium bicarbonate or potassium citrate.
Once the acute attack subsides, levels of uric acid can be lowered via lifestyle changes and in those with frequent attacks, allopurinol or probenecid provides long-term prevention.
Higher doses and rapid introduction of allopurinol and lamotrigine may also increase the risk of developing SJS/TEN.
Study 3, a 1 year study, randomized patients to: ULORIC 80 mg daily, ULORIC 120 mg daily, or allopurinol 300 mg daily.
Combining allopurinol with reduced doses of thiopurines promotes production of 6TGN over 6MMP, leading to optimal 6TGN concentrations and improved clinical benefit in hypermethylators, they explained.