allosteric
Speech parts
1. allosteric - Noun
2. allosteric - Adjective
Meaning
allosteric (comparative more allosteric, superlative most allosteric)
(biochemistry, of an enzyme) That binds a compound on an inactive site and thus changes macromolecular conformation or dynamics in order to become either active or inactive
allosteric (plural allosterics)
(biochemistry) An allosteric modulator
Anagrams
Examples
ATP competes with AMP for the allosteric effector site on the PFK enzyme.
Iron's shift to a higher oxidation state in Hb-O 2 decreases the atom's size, and allows it into the plane of the porphyrin ring, pulling on the coordinated histidine residue and initiating the allosteric changes seen in the globulins.
In some cases, the inhibitor can bind to a site other than the binding-site of the usual substrate and exert an allosteric effect to change the shape of the usual binding-site.
One recognition site acts as the target for cleavage, while the other acts as an allosteric effector that speeds up or improves the efficiency of enzyme cleavage.
There is no known allosteric mechanism that can account for large changes in reaction rate from an allosteric effector whose concentration changes less than 10%. citation Calcium is used as a regulator.
These functions are, in part, controlled by allosteric modification by secondary messengers and reversible protein phosphorylation.