Noun
aprepitant (countable and uncountable, plural aprepitants)
(pharmacology) An antiemetic drug C23H21F7N4O3 taken orally to prevent nausea and vomiting occurring as a consequence of cancer chemotherapy or surgery. It acts as an antagonist of receptors for substance P. It is often taken in combination with other antiemetic drugs and is marketed under the trademark Emend.
Due to modest decreases in protein binding of aprepitant in patients with renal disease, the AUC of pharmacologically active unbound drug was not significantly affected in patients with renal impairment compared with healthy subjects. Source: Internet
Following oral administration of a single 125 mg dose of aprepitant on Day 1 and 80 mg once daily on Days 2 through 5, the AUC0-24hr of aprepitant was 21% higher on Day 1 and 36% higher on Day 5 in elderly (65 years and older) relative to younger adults. Source: Internet