Noun
a lymphocyte derived from bone marrow that provides humoral immunity; it recognizes free antigen molecules in solution and matures into plasma cells that secrete immunoglobulin (antibodies) that inactivate the antigens
Source: WordNetB-cell
An example is PAX5 factor, which is important in B cell development and associated with lymphomas. citation Surprisingly, pax5 conditional knock out mice allowed peripheral mature B cells to de-differentiate to early bone marrow progenitors. Source: Internet
BAFF stimulates aberrant B-cell maturation, leading to the emergence of self-reactive B cells, which locally produce autoantibodies, in a germinal centre -like structure (GC-like), which is also the location of lymphomagenesis (origin of lymphoma ). Source: Internet
In the bone marrow, each developing B cell will assemble an immunoglobulin variable region by randomly selecting and combining one V, one D and one J gene segment (or one V and one J segment in the light chain). Source: Internet
"Our youngest our 2-year-old, just after her 1st birthday she was diagnosed with high-risk B cell acute lymphoblastic leukemia," parent, Kari Lucas said. Source: Internet
"B cell localization and migration in health and disease." Source: Internet
For example, the M-001 formulation was chosen because these tiny epitopes spark both T cell and B cell immune responses. Source: Internet