Barr body
Noun
Meaning
Barr body (plural Barr bodies)
(biology) A sex chromosome inactivated by packing in heterochromatin.
Men with Klinefelter syndrome (47,XXY karyotype) have a single Barr body, whereas women with a 47,XXX karyotype have two Barr bodies.
Examples
A Barr body (named after discoverer Murray Barr ) Barr, M. L., Bertram, E. G., (1949), A Morphological Distinction between Neurones of the Male and Female, and the Behaviour of the Nucleolar Satellite during Accelerated Nucleoprotein Synthesis.
Left: DAPI stained female human fibroblast with Barr body (arrow).
It is thought that this constitutes the mechanism of choice, and allows downstream processes to establish the compact state of the Barr body.
The Barr body is indicated by the arrow, it identifies the inactive X (Xi).