1. breakthrough - Noun
2. breakthrough - Adjective
making an important discovery
a penetration of a barrier such as an enemy's defense
a productive insight
Source: WordNetThe obvious mathematical breakthrough would be development of an easy way to factor large prime numbers. Bill Gates
In thinking about nanotechnology today, what's most important is understanding where it leads, what nanotechnology will look like after we reach the assembler breakthrough. K. Eric Drexler
I always did something I was a little not ready to do. I think that's how you grow. When there's that moment of 'Wow, I'm not really sure I can do this,' and you push through those moments, that's when you have a breakthrough. Marissa Mayer
America has the best doctors, the best nurses, the best hospitals, the best medical technology, the best medical breakthrough medicines in the world. There is absolutely no reason we should not have in this country the best health care in the world. Bill Frist
The technological breakthrough of the World Wide Web has been enormously beneficial to society. Mike Fitzpatrick
While that amendment failed, human cloning continues to advance and the breakthrough in this unethical and morally questionable science is around the corner. Mike Pence