C-terminal
Noun
Meaning
C-terminal (plural C-terminals)
Alternative form of C-terminus
Examples
A chemically synthesized c-terminal tail is then grafted onto insulin by reverse proteolysis using the inexpensive protease trypsin; typically the lysine on the c-terminal tail is protected with a chemical protecting group to prevent proteolysis.
A further member of this class is the RNA polymerase II C-terminal domain phosphatase.
Most commonly, they create an isopeptide bond between a lysine of the target protein and the C-terminal glycine of ubiquitin.
Examples are the C-terminal SH3 domains of adaptor proteins like Grb2 and Mona (a.
Proteins are often synthesized in an inactive precursor form; typically, an N-terminal or C-terminal segment blocks the active site of the protein, inhibiting its function.
HIV integrase is a 32 kDa protein produced from the C-terminal portion of the Pol gene product, and is an attractive target for new anti-HIV drugs.