calamity
Noun
Meaning
Any great misfortune or cause of misery; -- generally applied to events or disasters which produce extensive evil, either to communities or individuals.
A state or time of distress or misfortune; misery.
Source: Webster's dictionarySynonyms
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Examples
It is a persistent evil to persecute a man who belongs to the grace of God. It is a calamity without remedy to hate the happy.
Learn to see in another's calamity the ills which you should avoid.
Have the courage to be ignorant of a great number of things, in order to avoid the calamity of being ignorant of everything.
The first day a guest, the second day a guest, the third day a calamity.
He appreciates prosperity who is caught in calamity.
The mouth is the cause of calamity.