The central problem of novel-writing is causality. Jorge Luis Borges
Both of us had decided, quite independently of each other, that the central problem in molecular biology was the chemical structure of the gene. Francis Crick
That conflict between the reach for the divine and the lure of earthly things was to be the central problem of the Middle Ages. Barbara Tuchman
Complexity control is the central problem of writing software in the real world. Eric S. Raymond
What we really mean by free will... is the visualizing of alternatives and making a choice between them. ...the central problem of human consciousness depends on this ability to imagine. Jacob Bronowski
[J]ustification of power must be the central problem. For it is through this problem alone that freedom and equality-or... justice-can be projected into the social and political reality... But to fascism the problem does not even exist except as a ridiculous relic of "Jewish liberalism." Peter Drucker