The brain is a mystery; it has been and still will be. How does the brain produce thoughts? That is the central question and we have still no answer to it. Charles Scott Sherrington
The central question of economic policy is the question of the effectiveness of its various instruments. Jan Tinbergen
The central question is simply put: What did the president know and when did he know it? Howard Baker
The central question is whether Medicare and Medicaid should remain entitlement programs guaranteeing a certain amount of care, as Democrats believe, or become defined contribution programs in which federal spending is capped, as Republicans suggest. Christina Romer
So this, I believe, is the central question upon which all creative living hinges: Do you have the courage to bring forth the treasures that are hidden within you? Elizabeth Gilbert
In an age of constant live connections, the central question of self-examination is drifting from ‘Who are you?' towards ‘What are you doing? Tom Chatfield