clozapine
Noun
Meaning
an antipsychotic drug (trade name Clozaril) used as a sedative and for treatment-resistant schizophrenia; know to have few side effects
Source: WordNetSynonyms
Hypernyms
Examples
Antipsychotics All antipsychotic substances, except clozapine, are relatively potent postsynaptic dopamine receptor blockers (dopamine antagonists ).
All of the effective antipsychotics, except clozapine, act on the nigrostriatal system.
It has been recommended that patients, families, and caregivers are aware of the symptoms and risks of abrupt withdrawal of clozapine.
For example, drugs used to treat patients with schizophrenia such as haloperidol, chlorpromazine, and clozapine are antagonists at receptors in the brain for dopamine.
If carbamazepine is discontinued or the dose of carbamazepine is decreased, therapeutic effects of clozapine should be monitored.
The elimination half-life of clozapine is about 14 hours at steady state conditions (varying with daily dose).