cofactor
Noun
Meaning
a substance (as a coenzyme) that must join with another to produce a given result
Source: WordNetSynonyms
Hypernyms
Phrases with the word
Examples
L -Gulonolactone then reacts with oxygen, catalyzed by the enzyme L -gulonolactone oxidase (which is nonfunctional in humans and other Haplorrhini primates) and the cofactor FAD+.
Dihydrobiopterin reductase activity is needed to replenish quinonoid-dihydrobiopterin back into its tetrahydrobiopterin form, which is an important cofactor in many reactions in amino acid metabolism.
For example, ICP-MS may be combined with size exclusion chromatography and quantitative preparative native continuous polyacrylamide gel electrophoresis ( QPNC-PAGE ) for identifying and quantifying native metal cofactor containing proteins in biofluids.
Except for the ancient nitrogenases, all known Mo-using enzymes use this cofactor.
Fungal prions have helped to suggest mechanisms of conversion that may apply to all prions, though fungal prions appear distinct from infectious mammalian prions in the lack of cofactor required for propagation.
However, if there is not enough of the PAH enzyme or its cofactor, then phenylalanine can build up in the blood and brain to toxic levels, affecting brain development and function.