Another well-known afferent is the nigrostriatal connection arising from the neurons of the substantia nigra pars compacta. Source: Internet
However, lack of pars compacta neurons has a large influence on movement, as evidenced by the symptoms of Parkinson's. Source: Internet
However, some contributions to the unique susceptibility of dopaminergic neurons in the pars compacta have been identified. Source: Internet
Parkinson's disease is usually associated with a degraded substantia nigra pars compacta, but recent evidence suggests that PD affects a number of sites in the brain. Source: Internet
The dopaminergic pathway from the substantia nigra pars compacta to the striatum is shown in light blue. Source: Internet
The pars compacta sends excitatory input to the striatum via D1 pathway that excites and activates the striatum, resulting in the release of GABA onto the globus pallidus to inhibit its inhibitory effects on the thalamic nucleus. Source: Internet