COMT
Noun
Meaning
COMT (plural COMTs)
(biochemistry) Initialism of catechol-O-methyltransferase.
Phrases with the word
Anagrams
Examples
This has be postulated to be explained by variations of the gene which codes for the enzyme catechol-O-methyl transferase (COMT) which may produce 3 different phenotypes with regards pain sensitivity.
These create dopamine, which then experiences methylation by a catechol-O-methyltransferase (COMT) by an S-adenosyl methionine (SAM)-dependent mechanism.
The variation of the COMT gene which produces less of this enzyme is associated with a high sensitivity to pain.
It turns out that I am also homozygous for the COMT gene which means that I have an 80% decreased capacity to clear estrogen (thanks mom and dad!).
For some of our patients, one of the tests we do is looking for genetic predispositions as they relate to methylation, and one of those is COMT.