Word info

Curtius rearrangement

Noun

Meaning

Curtius rearrangement (plural Curtius rearrangements)

(chemistry) The thermal decomposition of an acyl azide to an isocyanate with loss of nitrogen gas. The isocyanate then undergoes attack by a variety of nucleophiles such as water, alcohols and amines, to yield a primary amine, carbamate or urea derivative respectively.
Synonyms: Curtius degradation, Curtius reaction

Source: en.wiktionary.org

Examples

This synthetic intermediate can be transformed into amphetamine using either a Hofmann or Curtius rearrangement (method 4). Source: Internet

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