cytochrome

Noun

Meaning

(biochemistry) a class of hemoprotein whose principal biological function is electron transfer (especially in cellular respiration)

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Examples

Clozapine is extensively metabolized in the liver, via the cytochrome P450 system, to polar metabolites suitable for elimination in the urine and feces. Source: Internet

Ciprofloxacin is weakly bound to serum proteins (20-40%), but is an inhibitor of the drug-metabolizing enzyme cytochrome P450 1A2, which leads to the potential for clinically important drug interactions with drugs metabolized by that enzyme. Source: Internet

For example, patients with sulfonamide-induced toxic epidermal necrolysis have been shown to have a slow acetylator genotype that results in increased production of sulfonamide hydroxylamine via the cytochrome P-450 pathway. Source: Internet

DDT resistance is also conferred by up-regulation of genes expressing cytochrome P450 in some insect species, citation as greater quantities of some enzymes of this group accelerate the toxin's metabolism into inactive metabolites. Source: Internet

In 1946, he concluded that cytochrome oxidase and other enzymes responsible for the respiratory chain were isolated to the mitchondria. Source: Internet

DHEA is produced from cholesterol through two cytochrome P450 enzymes. Source: Internet

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