domoic
Adjective
Meaning
domoic (not comparable)
Of or pertaining to domoic acid or its derivatives
Anagrams
Examples
Domoic acid is an excitatory amino acid analogue of glutamate; a neurotransmitter in the brain that activates glutamate receptors.
Domoic acid can bioaccumulate in marine organisms such as shellfish, anchovies, and sardines that feed on the phytoplankton known to produce this toxin.
Domoic acid has a very strong affinity for these receptors, which results in excitotoxicity initiated by an integrative action on ionotropic glutamate receptors at both sides of the synapse blocking the channel from rapid desensitization.
Domoic acid is a neurotoxin that inhibits neurochemical processes, causing short-term memory loss, brain damage, and, in severe cases, death in humans.
In marine mammals, domoic acid typically causes seizures and tremors.
In the 1987 domoic acid poisoning on Prince Edward Island concentrations ranging from 0.31–1.28 mg/kg of muscle tissue were noted in people that became ill (three of whom died).