Impaired DNA repair mechanisms may contribute to earlier depletion of the ovarian reserve during aging. citation As women age, double-strand breaks accumulate in the DNA of their primordial follicles. Source: Internet
Errors introduced during DNA repair seeAlso Although naturally occurring double-strand breaks occur at a relatively low frequency in DNA, their repair often causes mutation. Source: Internet
Chromosomal ends might also be processed as breaks in double-strand DNA with chromosome-to-chromosome telomere fusions resulting. Source: Internet
It catalyzes the final step in the non-homologous end joining DNA double-strand break repair pathway. Source: Internet
During the microtubule-based transport to the nucleus, the viral single-strand RNA genome is transcribed into double-strand DNA, which is then integrated into a host chromosome. Source: Internet
Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans. Source: Internet