Noun
down-regulation (uncountable)
Alternative spelling of downregulation
down regulation
Another mechanism of epilepsy may be the up-regulation of excitatory circuits or down-regulation of inhibitory circuits following an injury to the brain. Source: Internet
Drosophila is known to use the Polycomb and Trithorax Complexes to maintain the expression of Hox genes after the down-regulation of the pair-rule and gap genes that occurs during larval development. Source: Internet
However, repeated exposure to hallucinogens leads to rapid tolerance, likely through down-regulation of these receptors in specific target cells. Source: Internet
The reaction of the target cells may then be recognized by the original hormone-producing cells, leading to a down-regulation in hormone production. Source: Internet
These factors can increase or decrease gene transcription and thus increase or decrease the generation of new receptors (up- or down-regulation) that travel to the cell membrane. Source: Internet