downregulation

Noun

Meaning

(biology) The suppression of a response to a stimulus

(genetics) The process, in the regulation of gene expression, in which the number, or activity of receptors decreases in order to decrease sensitivity

Examples

Physical addiction to cocaine may result from prolonged exposure to excess dopamine in the synapses, which leads to the downregulation of some post-synaptic receptors. Source: Internet

The downregulation of GABA pathways, which serve an inhibitory function and are involved in learning and memory, may be a factor in the anxiety symptoms which are commonly seen in FXS. Source: Internet

Close letter words and terms