endosome
Noun
Meaning
English Wikipedia has an article on:endosomeWikipedia
endosome (plural endosomes)
(biology) An endocytic vacuole through which molecules internalized during endocytosis pass en route to lysosomes
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Downregulation occurs when endocytosed receptor is embedded in an endosome that is trafficked to merge with an organelle called a lysosome.
The late endosome itself can eventually grow into a mature lysosome, as evidenced by the transport of endosomal membrane components from the lysosomes back to the endosomes.
Inside the endosome, the toxin is split by a trypsin-like protease into its individual A and B fragments.
The low pH within the endosome then triggers BTV's membrane penetration protein VP5 to undergo a conformational change that disrupts the endosomal membrane.