glecaprevir
Noun
Meaning
glecaprevir (uncountable)
(pharmacology) A protease inhibitor used to treat hepatitis C.
Examples
Combinations of NS3 Y56H plus D/Q168 substitutions resulted in greater reductions in glecaprevir susceptibility.
In HCV replicon assays, glecaprevir had median EC values of 0.08-4.6 nM against laboratory and clinical isolates from subtypes 1a, 1b, 2a, 2b, 3a, 4a, 4d, 5a, and 6a.
Maternal systemic exposure (AUC) to glecaprevir and pibrentasvir was approximately 47 or 74 times the exposure in humans at the RHD.