globin
Noun
Meaning
a colorless protein obtained by removing heme from hemoglobin; the oxygen carrying compound in red blood cells
Source: WordNetSynonyms
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Nitric oxide is bound to specific thiol groups in the globin protein to form an S-nitrosothiol, which dissociates into free nitric oxide and thiol again, as the hemoglobin releases oxygen from its heme site.
Hemoglobin also carries nitric oxide (NO) in the globin part of the molecule.
Hemoglobinopathies results from the abnormal structure of One of the globin chains of the hemoglobin molecule (mutation of alpha and/or beta globin chain resulting in a variant form of Hemoglobin A).
In all these groups, heme/globin-containing molecules (even monomeric globin ones) that deal with gas-binding are referred to as oxyhemoglobins.
NO binds reversibly to a specific cysteine residue in globin; the binding depends on the state (R or T) of the hemoglobin.
For example, the most common hemoglobin sequences in humans and chimpanzees are nearly identical, differing by only one amino acid in both the alpha and the beta globin protein chains.