gluconeogenesis

Noun

Meaning

gluconeogenesis (usually uncountable, plural gluconeogeneses)

(biochemistry) The metabolic process in which glucose is formed, mostly in the liver, from non-carbohydrate precursors

Synonyms

Anagrams

Examples

After the glycogen stores have been depleted, both gluconeogenesis and the production of ketone bodies by liver fatty acid beta-oxidation (or β-oxidation) are essential… Source: Internet

Glucagon and epinephrine also stimulate gluconeogenesis, which coverts non-carbohydrate substrates into G6P, which joins the G6P derived from glycogen, or substitutes for it when the liver glycogen store have been depleted. Source: Internet

During gluconeogenesis mitochondrial oxaloacetate is reduced to malate which is then transported out of the mitochondrion, to be oxidized back to oxaloacetate in the cytosol. Source: Internet

In the liver, therefore, oxaloacetate is unavailable for condensation with acetyl-CoA when significant gluconeogenesis has been stimulated by low (or absent) insulin and high glucagon concentrations in the blood. Source: Internet

However, if gluconeogenesis is underway in the cytosol, the latter reducing equivalent is used to drive the reversal of the GAPDH step instead of generating ATP. Source: Internet

In the liver the glycerol can be converted into glucose via dihydroxyacetone phosphate and glyceraldehyde-3-phosphate by way of gluconeogenesis. Source: Internet

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