Noun
gluconeogenesis (usually uncountable, plural gluconeogeneses)
(biochemistry) The metabolic process in which glucose is formed, mostly in the liver, from non-carbohydrate precursors
After the glycogen stores have been depleted, both gluconeogenesis and the production of ketone bodies by liver fatty acid beta-oxidation (or β-oxidation) are essential… Source: Internet
Glucagon and epinephrine also stimulate gluconeogenesis, which coverts non-carbohydrate substrates into G6P, which joins the G6P derived from glycogen, or substitutes for it when the liver glycogen store have been depleted. Source: Internet
During gluconeogenesis mitochondrial oxaloacetate is reduced to malate which is then transported out of the mitochondrion, to be oxidized back to oxaloacetate in the cytosol. Source: Internet
In the liver, therefore, oxaloacetate is unavailable for condensation with acetyl-CoA when significant gluconeogenesis has been stimulated by low (or absent) insulin and high glucagon concentrations in the blood. Source: Internet
However, if gluconeogenesis is underway in the cytosol, the latter reducing equivalent is used to drive the reversal of the GAPDH step instead of generating ATP. Source: Internet
In the liver the glycerol can be converted into glucose via dihydroxyacetone phosphate and glyceraldehyde-3-phosphate by way of gluconeogenesis. Source: Internet