gp120
Noun
Meaning
gp120 (uncountable)
A glycoprotein exposed on the surface of the HIV envelope, playing a vital role in attachment to specific cell surface receptors.
Examples
2. Conformational change in gp120 allows for secondary interaction with CCR5.
For example, env codes for a protein called gp160 that is cut in two by a cellular protease to form gp120 and gp41.
HIV-1 entry to macrophages and CD4 + T cells is mediated through interaction of the virion envelope glycoproteins (gp120) with the CD4 molecule on the target cells and also with chemokine coreceptors.
Once gp120 is bound with the CD4 protein, the envelope complex undergoes a structural change, exposing the chemokine binding domains of gp120 and allowing them to interact with the target chemokine receptor.
The first step in fusion involves the high-affinity attachment of the CD4 binding domains of gp120 to CD4.