Noun
gp120 (uncountable)
A glycoprotein exposed on the surface of the HIV envelope, playing a vital role in attachment to specific cell surface receptors.
2. Conformational change in gp120 allows for secondary interaction with CCR5. Source: Internet
For example, env codes for a protein called gp160 that is cut in two by a cellular protease to form gp120 and gp41. Source: Internet
HIV-1 entry to macrophages and CD4 + T cells is mediated through interaction of the virion envelope glycoproteins (gp120) with the CD4 molecule on the target cells and also with chemokine coreceptors. Source: Internet
Once gp120 is bound with the CD4 protein, the envelope complex undergoes a structural change, exposing the chemokine binding domains of gp120 and allowing them to interact with the target chemokine receptor. Source: Internet
The first step in fusion involves the high-affinity attachment of the CD4 binding domains of gp120 to CD4. Source: Internet