HIV-1
Noun
Meaning
HIV-1 (uncountable)
Initialism of human immunodeficiency virus 1.
Synonyms
Examples
Antiretroviral effect of MK-0518, a novel HIV-1 integrase inhibitor, in ART-naïve HIV-1 infected patients.
Additional genotypic tests evaluate resistance to integrase strand-displacement inhibitors (HIV-1 Integrase Genotype assay) and to the HIV fusion inhibitor enfuvirtide (HIV-1 gp41 Envelope Genotype assay).
HIV-1 infection causes chronic ongoing inflammation and production of reactive oxygen species. citation Thus, the HIV genome may be vulnerable to oxidative damages, including breaks in the single-stranded RNA.
HIV-1 entry to macrophages and CD4 + T cells is mediated through interaction of the virion envelope glycoproteins (gp120) with the CD4 molecule on the target cells and also with chemokine coreceptors.
Gag proteins bind to copies of the virus RNA genome to package them into new virus particles. citation HIV-1 and HIV-2 appear to package their RNA differently.
HIV-1 is the virus that was initially discovered and termed both LAV and HTLV-III.