hypoxanthine
Noun
Meaning
English Wikipedia has an article on:hypoxanthineWikipedia
hypoxanthine (countable and uncountable, plural hypoxanthines)
(organic chemistry) A bicyclic heterocycle, 3,7-dihydropurin-6-one, that is an intermediate in the biosynthesis of uric acid.
Synonyms
Examples
Examples include C → U and A → HX ( hypoxanthine ), which can be corrected by DNA repair mechanisms; and 5MeC ( 5-methylcytosine ) → T, which is less likely to be detected as a mutation because thymine is a normal DNA base.
Similarly, uric acid can be formed when AMP is deaminated to IMP from which the ribose unit is removed to form hypoxanthine.
It is an analog of hypoxanthine that is hydroxylated by xanthine oxidoreductase at the 2-position to give oxipurinol.