isoform
Noun
Meaning
English Wikipedia has an article on:protein isoformWikipedia
isoform (plural isoforms)
(biochemistry) Any of several different forms of the same protein, arising from either single nucleotide polymorphisms, differential splicing of mRNA, or post-translational modifications (e.g. sulfation, glycosylation, etc.)
Synonyms
Related terms
Examples
Because the signal transducing properties of the various possible βγ combinations do not appear to radically differ from one another, these classes are defined according to the isoform of their α-subunit.
In addition, a conformation that preferably activates one isoform of Gα may activate another if the preferred is less available.
Interestingly, the amount of fully activated Th (Serine40-phosphorylated isoform) in neurons that remain in the SNpc is mildly affected at 5 weeks but severely impaired by 9 weeks.
The relative amount of each isoform can also easily and rapidly be determined from staining intensity on 2D gels.
"Isoform specific treatments hold great promise for the design of targeted therapies to treat neurological diseases with much greater efficacy and accuracy than those utilizing a one-size-fits-all approach," the authors conclude.