Noun
ligase (plural ligases)
(biochemistry) Any of a group of enzymes that catalyze the binding of two molecules; synthetase.
HIF is synthesized consititutively, and hydroxylation of at least one of two critical proline residues mediates their interaction with the von Hippel Lindau E3 ubiquitin ligase complex, which targets them for rapid degradation. Source: Internet
DNA ligase is used in both DNA repair and DNA replication (see Mammalian ligases ). Source: Internet
It plays a role in repairing single-strand breaks in duplex DNA in living organisms, but some forms (such as DNA ligase IV ) may specifically repair double-strand breaks (i.e. a break in both complementary strands of DNA). Source: Internet
The absence of stably annealed ends also means that the ligation efficiency is lowered, requiring a higher ligase concentration to be used. Source: Internet
It can also ligate blunt-ended DNA with much greater efficiency than E. coli DNA ligase. Source: Internet
Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, citation with DNA ligase creating the final phosphodiester bond to fully repair the DNA. Source: Internet