Humor is by far the most significant activity of the human brain. Edward de Bono
What was most significant about the lunar voyage was not that men set foot on the moon but that they set eye on the earth. Norman Cousins
All around us are the consequences of the most significant technological, and hence cultural, revolution in generations. Lawrence Lessig
Silence accompanies the most significant expressions of happiness and unhappiness: those in love understand one another best when silent, while the most heated and impassioned speech at a graveside touches only outsiders, but seems cold and inconsequential to the widow and children of the deceased. Anton Chekhov
In the judgment of the most competent living mathematicians, Fräulein Noether was the most significant creative mathematical genius thus far produced since the higher education of women began. Albert Einstein
One of the most significant facts about us may finally be that we all begin with the natural equipment to live a thousand kinds of life but end in the end having lived only one. Clifford Geertz