MPTP

Noun

Meaning

(neurotoxicology) A byproduct of synthetic heroin, or MPPP, which causes Parkinsonian symptoms in users.

(neurotoxicology) A neurotoxin which degrades into MPP+ after crossing the blood brain barrier, which causes a degredation of the dopaminergic neurons within the substantia nigra.

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Examples

Today, MPTP remains the most favored neurotoxin to model nigrostriatal degeneration and dopamine depletion in animals, for studying Parkinson's disease. Source: Internet

Various compounds such as levodopa and MPTP are used in the treatment and study of Parkinson's disease, and many other drugs have effects on the substantia nigra. Source: Internet

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