muscimol
Noun
Meaning
muscimol (uncountable)
(biochemistry) A hallucinogenic alkaloid present in the fly agaric and other related fungi; 3-hydroxy-5-aminomethylisoxazole. [from 20th c.]
Examples
Almost no muscimol is excreted when pure ibotenic acid is eaten, but muscimol is detectable in the urine after eating A. muscaria, which contains both ibotenic acid and muscimol.
An active dose in adults is approximately 6 mg muscimol or 30 to 60 mg ibotenic acid; citation citation this is typically about the amount found in one cap of Amanita muscaria.
Fos-labeled cell analysis showed that the PMDvl is the most activated structure in the hypothalamus, and inactivation with muscimol prior to exposure to the context abolishes the defensive behavior.
Drying may increase potency, as the process facilitates the conversion of ibotenic acid to the more potent muscimol.
Researchers in England, citation Japan, citation and Switzerland citation showed that the effects produced were due mainly to ibotenic acid and muscimol, not muscarine.
Spring and summer mushrooms have been reported to contain up to 10 times more ibotenic acid and muscimol than autumn fruitings.