nigrostriatal
Adjective
Meaning
nigrostriatal (not comparable)
Pertaining to a neural connection between the substantia nigra and the striatum.
Related terms
Anagrams
Examples
Altogether, these results argue for an alteration of the nigrostriatal dopaminergic pathway in MeCP2-deficient animals as a contributor of the neuromotor deficits.
Another well-known afferent is the nigrostriatal connection arising from the neurons of the substantia nigra pars compacta.
All of the effective antipsychotics, except clozapine, act on the nigrostriatal system.
In primates, dopaminergic neuron activity increases in the nigrostriatal pathway when a new stimulus is presented. citation Dopaminergic activity decreases with repeated stimulus presentation.
Today, MPTP remains the most favored neurotoxin to model nigrostriatal degeneration and dopamine depletion in animals, for studying Parkinson's disease.