A request, usually rhetorical, to know what, in a series of negative events, is the next negative event occurring.
A request for advice or instruction on what should be done, when a situation has turned negative, particularly if a contingency has failed.
Source: en.wiktionary.orgThese Restaurants Were Hoping to Open For The First Time This Spring: Now What? Source: Internet
After North Korea's ICBM Launch, Now What? Source: Internet