Noun
(Pokémon) A self-imposed challenge where the player can only catch the first wild Pokémon encountered in each area, and any caught Pokémon that faints cannot be used again.
(by extension) A similarly challenging playthrough of any game other than Pokémon.
nuzlocke (plural nuzlockes)
Alternative letter-case form of Nuzlocke
Pokémon: What is the Nuzlocke Challenge - and Why Is It So Popular? Source: Internet