oxaloacetate

Noun

Meaning

a salt or ester of oxalacetic acid

Synonyms

Hypernyms

Examples

De-aminated alanine, cysteine, glycine, serine, and threonine are converted to pyruvate and can consequently either enter the citric acid cycle as oxaloacetate (an anaplerotic reaction) or as acetyl-CoA to be disposed of as CO 2 and water. Source: Internet

Below is a schematic outline of the cycle: * The citric acid cycle begins with the transfer of a two-carbon acetyl group from acetyl-CoA to the four-carbon acceptor compound (oxaloacetate) to form a six-carbon compound (citrate). Source: Internet

During gluconeogenesis mitochondrial oxaloacetate is reduced to malate which is then transported out of the mitochondrion, to be oxidized back to oxaloacetate in the cytosol. Source: Internet

In the liver, therefore, oxaloacetate is unavailable for condensation with acetyl-CoA when significant gluconeogenesis has been stimulated by low (or absent) insulin and high glucagon concentrations in the blood. Source: Internet

Other biological roles Citrate can be transported out of the mitochondria and into the cytoplasm, then broken down into acetyl-CoA for fatty acid synthesis and into oxaloacetate. Source: Internet

A transaminase converts the oxaloacetate to aspartate for transport back across the membrane and into the intermembrane space. Source: Internet

Close letter words and terms