p53

Noun

Meaning

p53 (uncountable)

A regulatory protein that is often mutated in human cancers.

Examples

Activated p53 binds DNA and activates expression of several genes including microRNA miR-34a, citation WAF1/CIP1 encoding for p21 and hundreds of other down-stream genes. Source: Internet

As a consequence, p53 cannot induce apoptosis, since it cannot induce the expression of proapoptotic proteins. Source: Internet

Another important tumor suppressor is the p53 tumor-suppressor protein encoded by the TP53 gene. Source: Internet

A mutant p53 will no longer bind DNA in an effective way, and, as a consequence, the p21 protein will not be available to act as the "stop signal" for cell division. Source: Internet

Any disruption to the regulation of the p53 or interferon genes will result in impaired apoptosis and the possible formation of tumors. Source: Internet

All these p53 proteins are called the p53 isoforms. Source: Internet

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