pembrolizumab
Noun
Meaning
pembrolizumab (uncountable)
(pharmacology) A drug that targets the programmed cell death 1 (PD-1) receptor, intended for use in treating metastatic melanoma.
Synonyms
Examples
The clinical benefit of pembrolizumab in advanced thyroid cancer will be further studied in a follow-up phase II clinical trial that is now ongoing to try to discover biomarkers which predict response to treatment with pembrolizumab.
The biomarker cut point will need to be validated in the larger study population, but seems to identify patients most likely to respond to pembrolizumab well.
The phase II KEYNOTE-052 trial evaluated the efficacy and safety of PD-1 blockade with pembrolizumab as first line therapy in cisplatin ineligible patients with metastatic or locally advanced bladder cancer.