phosphofructokinase
Noun
Meaning
phosphofructokinase (plural phosphofructokinases)
(biochemistry) Any of a group of kinase enzymes that convert fructose phosphates to biphosphates
Synonyms
Phrases with the word
Examples
Fructose 2,6-bisphosphate (F2,6BP) is a very potent activator of phosphofructokinase (PFK-1) that is synthesized when F6P is phosphorylated by a second phosphofructokinase ( PFK2 ).
The main control point for the glycolytic pathway is phosphofructokinase (PFK), which is allosterically inhibited by high concentrations of ATP and activated by high concentrations of AMP.
If the intracellular pH changes to 5 or lower, the anaerobic fermentation of glucose through phosphofructokinase is decreased by 95%.
In the second regulated step (the third step of glycolysis), phosphofructokinase converts fructose-6-phosphate into fructose-1,6-bisphosphate, which then is converted into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate.
This reaction is catalyzed by phosphofructokinase.