phospholipase
Noun
Meaning
phospholipase (plural phospholipases)
(biochemistry) Any of several enzymes that hydrolyze the phosphate ester bonds of phospholipids.
Examples
Aristolochic acid inhibits the activity of snake venom phospholipase (PLA2) by forming a 1:1 complex with the enzyme.
G αq/11 G αq/11 stimulates the membrane-bound phospholipase C beta, which then cleaves PIP 2 (a minor membrane phosphoinositol ) into two second messengers, IP3 and diacylglycerol (DAG).
Since phospholipase enzymes play a significant part in the cascade leading to the inflammatory and pain response, their inhibition could lead to relief of problems from scorpion envenomation.
These proteins usually have phospholipase C as effector protein.
This is true in the case of phospholipase C -beta, which possesses GAP activity within its C-terminal region.