phosphorylase
Noun
Meaning
phosphorylase (plural phosphorylases)
(biochemistry) Any enzyme that catalyzes the production of glucose phosphate from glycogen and inorganic phosphate
Examples
Earl Sutherland explained in 1950, that the activity of phosphorylase was increased and thus glycogenolysis stimulated when liver slices were incubated with adrenalin and glucagon.
Carl and Gerty Cori found two forms of glycogen phosphorylase which they named A and B but did not correctly understand the mechanism of the B form to A form conversion.
He homogenized the liver into a membrane fraction and soluble fraction (phosphorylase is soluble), added norepinephrine to the membrane fraction, extracted its soluble products, and added them to the first soluble fraction.
The PLP-dependent transaminases and glycogen phosphorylase provide the vitamin with its role in gluconeogenesis, so deprivation of vitamin B 6 results in impaired glucose tolerance.
These enzymes are regulated in a reciprocal fashion, with phosphorylation inhibiting glycogen synthase, but activating phosphorylase.
They seem not to have glycogen phosphorylase, which is present in astrocytes to degrade glycogen.