polyubiquitinated
Adjective
Meaning
polyubiquitinated (not comparable)
ubiquitinated with a series of ubiquitin molecules
Examples
Each end of the core particle associates with a 19S regulatory subunit that contains multiple ATPase active sites and ubiquitin binding sites; it is this structure that recognizes polyubiquitinated proteins and transfers them to the catalytic core.
After a CDK-cyclin complex has performed its function, the associated cyclin is polyubiquitinated and destroyed by the proteasome, which provides directionality for the cell cycle.
The mechanism by which a polyubiquitinated protein is targeted to the proteasome is not fully understood.