postsynaptic
Adjective
Meaning
postsynaptic (not comparable)
(cytology) In a synapse, of or pertaining to the neuron that bears receptors for neurotransmitter released into the synaptic cleft by the presynaptic neuron.
Related terms
Examples
Acetylcholine binds to acetylcholine receptors at the postsynaptic membrane to open the sodium-channels there, generating a new action potential.
After chronic use, neurons adapt to the change in biochemistry, resulting in a change in pre- and postsynaptic receptor density and second messenger function.
Antipsychotics All antipsychotic substances, except clozapine, are relatively potent postsynaptic dopamine receptor blockers (dopamine antagonists ).
Chronic consumption is also associated with an effect on CREB phosphorylation and function via postsynaptic NMDA receptor signaling cascades through a MAPK/ERK pathway and CAMK -mediated pathway.
Binding of neurotransmitters may influence the postsynaptic neuron in either an inhibitory or excitatory way.
Depending on the type of receptor, the resulting effect on the postsynaptic cell may be excitatory, inhibitory, or modulatory in more complex ways.