primase
Noun
Meaning
English Wikipedia has an article on:primaseWikipedia
primase (plural primases)
(biochemistry) An RNA polymerase involved in the initiation of DNA synthesis.
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Examples
Along the lagging strand's template, primase builds RNA primers in short bursts.
Bacteria use a primase belonging to the DnaG protein superfamily which contains a catalytic domain of the TOPRIM fold type. citation The TOPRIM fold contains an α/β core with four conserved strands in a Rossmann-like topology.
In eukaryotic replication, the primase forms a complex with Pol α. citation Multiple DNA polymerases take on different roles in the DNA replication process.
In this mechanism, once the two strands are separated, primase adds RNA primers to the template strands.
The primase used by archaea and eukaryotes, in contrast, contains a highly derived version of the RNA recognition motif (RRM).