Noun
propranolol (countable and uncountable, plural propranolols)
(pharmacology) A synthetic compound which acts as a beta blocker and is used mainly in the treatment of cardiac arrhythmia.
However, it undergoes high first-pass metabolism by the liver and on average, only about 25% of propranolol reaches the systemic circulation. Source: Internet
On a basis, this dose in the mouse and rat is, respectively, about equal to and about twice the maximum recommended human oral daily dose (MRHD) of 640 mg propranolol hydrochloride. Source: Internet
In a series of reproduction and developmental toxicology studies, propranolol was given to ratsby gavage or in the diet throughout pregnancy and lactation. Source: Internet
Concomitant use of alcohol may increase plasma levels of propranolol. Source: Internet
In-vitro studies have indicated that the aromatic hydroxylation of propranolol is catalyzed mainly by CYP2D6. Source: Internet
Neonates whose mothers are receiving propranolol at have exhibited bradycardia, hypoglycemia and/or respiratory depression. Source: Internet