propranolol
Noun
Meaning
propranolol (countable and uncountable, plural propranolols)
(pharmacology) A synthetic compound which acts as a beta blocker and is used mainly in the treatment of cardiac arrhythmia.
Synonyms
Examples
However, it undergoes high first-pass metabolism by the liver and on average, only about 25% of propranolol reaches the systemic circulation.
On a basis, this dose in the mouse and rat is, respectively, about equal to and about twice the maximum recommended human oral daily dose (MRHD) of 640 mg propranolol hydrochloride.
In a series of reproduction and developmental toxicology studies, propranolol was given to ratsby gavage or in the diet throughout pregnancy and lactation.
Concomitant use of alcohol may increase plasma levels of propranolol.
In-vitro studies have indicated that the aromatic hydroxylation of propranolol is catalyzed mainly by CYP2D6.
Neonates whose mothers are receiving propranolol at have exhibited bradycardia, hypoglycemia and/or respiratory depression.