proteasome

Noun

Meaning

English Wikipedia has an article on:proteasomeWikipedia
proteasome (plural proteasomes)

(biochemistry) A complex protein, found in bacterial, archeal and eukaryotic cells, that breaks down other proteins via proteolysis.
Synonym: prosome

Examples

Assembly The assembly of the proteasome is a complex process due to the number of subunits that must associate to form an active complex. Source: Internet

Bortezomib (Boronated MG132), a molecule developed by Millennium Pharmaceuticals and marketed as Velcade, is the first proteasome inhibitor to reach clinical use as a chemotherapy agent. Source: Internet

After a CDK-cyclin complex has performed its function, the associated cyclin is polyubiquitinated and destroyed by the proteasome, which provides directionality for the cell cycle. Source: Internet

An improved and comprehensive understanding of the pathophysiology of the proteasome should lead to clinical applications in the future. Source: Internet

However, some cell lines — in particular, primary cultures of quiescent and differentiated cells such as thymocytes and neurons — are prevented from undergoing apoptosis on exposure to proteasome inhibitors. Source: Internet

In bacteria that express a 20S proteasome, the β subunits have high sequence identity to archaeal and eukaryotic β subunits, whereas the α sequence identity is much lower. Source: Internet

Close letter words and terms