quinolone

Noun

Meaning

(organic chemistry) Any of several isomeric ketones derived from quinoline.

(medicine) Any of a range of broad-spectrum antibiotics, related to nalidixic acid, based on this structure.

Related terms

Examples

Among the 46,766 quinolone users in the study, 38 (0.1%) cases of Achilles tendon rupture were identified. Source: Internet

History The first quinolone was nalidixic acid - introduced in 1962 for treatment of urinary tract infections in humans. citation Nalidixic acid was discovered by George Lesher and coworkers in a distillate during an attempt at chloroquine synthesis. Source: Internet

Nalidixic acid is thus considered to be the predecessor of all members of the quinolone family, including the second, third and fourth generations commonly known as fluoroquinolones. Source: Internet

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