RNA splicing
Noun
Meaning
RNA splicing (uncountable)
(genetics) A process in which the exons of a primary gene transcript, the pre-mRNA, are separated and reconnected so as to produce alternative ribonucleotide arrangements in the final mRNA
Examples
Guanosine is required for an RNA splicing reaction in mRNA, when a "self-splicing" intron removes itself from the mRNA message by cutting at both ends, re-ligating, and leaving just the exons on either side to be translated into protein.
However, different types of introns were identified through the examination of intron structure by DNA sequence analysis, together with genetic and biochemical analysis of RNA splicing reactions.
Splicing pathways Several methods of RNA splicing occur in nature; the type of splicing depends on the structure of the spliced intron and the catalysts required for splicing to occur.
MOs can knock down gene expression by inhibiting mRNA translation, blocking RNA splicing, or inhibiting miRNA activity and maturation.
Most RNA molecules are linear, single-stranded molecules, but both circular and branched molecules can result from RNA splicing reactions.